• - KDOG -

    A new and original cancer detection initiative

    An unprecedented, multidisciplinary team of caregivers, researchers and dog-loving experts has come together in a collaborative effort to place canine detection at the service of early cancer detection. Their method is both reliable, non-invasive and inexpensive.

  • KDOG: 100% success for the concept phase

    A nurse reveals the results at the Academy of Medicine

    Isabelle Fromantin, a nurse and doctor of science at the Curie Institute, presented on Tuesday, February 21, 2017, with Dr. Séverine Alran, before the French National Academy of Medicine, the first scientific results attesting the reliability of the Kdog project, giving it a positive dynamic for the future of the program. The result of the two detector dogs, Thor and Nykios, participating in the sample detection tests, reaches 100% of success.​

    Scientific results attesting to the reliability of Kdog

    After six months of training, Kdog finally reveals the results of these first tests, which prove its effectiveness. 

     

    The phase of samples recognition consists in two "passages" of the dog in front of the placed samples. By this we mean two exercises of sniffing the same samples interrupted by a pause. In the first pass, out of 31 patients sweat samples analyzed, 28 were detected positively by the dogs, which gives a result of 90.3% success. There is an evolution during the second pass of the dogs, with a rate of 100% success this time. The dogs were able to distinguish the healthy specimens and those with tumor markers.

     

    This first stage of project validation consolidates the objectives of the project and confidently launches the clinical study that will start in 2018 on the same principles observed during this proof of concept phase.

    A nurse presents the results

    She could present the results and perspectives of this promising and innovative project. First French nurse with a PhD in sciences and engineering, she is the spearhead of the Kdog project.

     

    Isabelle Fromantin joined the Curie Institute in 1993 where she worked in pediatrics and ENT surgery before participating in the creation of the first mobile unit of Palliative Care in a Center for the Fight against Cancer in 1997. She is a researcher associated with the Nursing Sciences Research Chair of the University Paris 13, Vice-President of the French and Francophone Society of Wounds and Cicatrization until 2017 and member of several Scientific Committees.

    Kdog is a Canine Based Cancer Screening Research Program using a reliable, reproducible, non-invasive and inexpensive method that offers an alternative to mammography in first intention. Kdog is based on the work of Dr. Isabelle Fromantin, a nurse at the Curie Institute, on the wounds and healings of breast cancer. Dogs, at the heart of the detection process, are trained by dog experts who work on olfactory memorization at a very low threshold for detecting infected cells on tumor samples and then on wipes.​

  • From idea to action…

    Photo © Philippe Brault / So On Pictures, 2016.

    It all started with an idea…

    Isabelle Fromantin is the first French nurse to be awarded a PhD in both science and engineering. Her thesis focused on the lesions and Healing processes related to breast cancer with the aim of better understanding patient’s issues and of finding solutions for those whom she cares for on a daily basis.

    Photo © Philippe Brault / So On Pictures, 2016.

    … followed by encounters with researchers…

    Her work has focused on materials (medical devices) which have been adapted to the pathophysiology of lesions (bacterial organization and biofilm), as well as to volatile organic compounds (notably the odors) of lesions. The aim of this work is to improve the quality of diagnosis and treatment available to vulnerable populations (oncology, geriatrics, emerging countries). She has brought together researchers and clinicians in order to strengthen the axis of her research, and to move towards the olfactory detection of cancer.

    … new energy is injected into the project…

    This is how the KDOG project was born: a multidisciplinary team composed of caregivers, pathologists, chemists and dog experts, who were all ready to place the formidable olfactory sensibility of dogs at the service of medical progress.

    To begin with, clinicians and pathologists will ensure the proper collection of samples. Dogs will be trained by dog experts to detect the odor of cancerous cells. Multiple training phases are necessary in order to lower the threshold of canine detection.

    Photo © Philippe Brault / So On Pictures, 2016.

    …with the aim of combating cancer all over the world!

    Using this method, tests will no longer need to be carried out on tumor biopsy samples, but on compresses placed directly on the patients’ skin, allowing for a "transcutaneous", non-invasive and painless screening. From the scientific evidence all the way to the design of the device itself, the KDOG project provides a response to the need to simplify diagnosis and make it available to all relevant populations and for all types of cancer. This reliable, simple and inexpensive detection method will therefore be easily adapteable and reproducible in emerging countries, where at the présent time many cancers go simply undiagnosed.

  • A great, big “thank you”…

    To all those who have participated in the KDOG project launch and who have allowed us,

    via Hello Asso or the Curie Institute, to acquire the necessary funding for this research.

    We were therefore able to halt the donation campaign.

     

    If you would like to support cancer research in a more comprehensive manner:

    https://aider.curie.fr/kdog/~mon-don/

     

    It is now our task to focus our energies on working to bring this beautiful project to fruition.

     

    We will of course keep you informed at every step of the way, via this website

    http://www.kdog.fr and our Facebook page

     

    The KDOG team

  • A multidisciplinary team at the heart of the project

    Caregivers from The Curie Institute

    Pathologists, nurses, surgeons, anesthetists... are jointly responsible for:

    • Collection and selection of samples suited to the training process of the dogs
    • Analysis of results according to basic research criteria
    • The establishment of a clinical study to validate the accuracy of the test
    • Monitoring and development of the project, and its expansion from breast cancer to all cancers

    Scientific research

    Chemists from ESPCI and Chimie Paris Tech shared their work on :

     

    • The detection method of volatile organic compounds (VOCs) by gas chromatography

    • The modeling of results

    • The scientific exchange between clinicians and dog experts on VOCs

     

    The dog experts

    The Malinois seem particularly suitable for this work: their excellent ability to learn and concentrate, as well as their endurance, make them excellent collaborators.

    Each dog is trained for between 14 and 18 months and can work on average until 9 years old. Training lasts 3 to 6 months, from primary olfactory memorization of samples to a very low threshold of detection of infected cells. (Learn more)

    The mobilization of an entire collective that takes part in this initiative

    Associations, former patients and concerned benefactors - an entire team has already been mobilized with energy and cheerfulness around this project, and whose wish it is also to be civic and collaborative.

    Do you want to join us?

    Initiating debates, communication…

    If you want to help us be successful together in this challenge, contact us !

  • Thanks to our partners

  • Contact us

    To keep you informed of progress, to offer us a helping hand, give us courage, to meet us…

    An original adventure proudly copilotted by Curie Institute and Les Petits Débrouillards